Beilstein J. Org. Chem.2014,10, 2566–2572, doi:10.3762/bjoc.10.268
-intermediates in DNA- and RNAzymes via an efficient and straightforward domino carboxamidation reaction.
Keywords: amino acids; bioorganic chemistry; carboxamidation reaction; chemically modified; DNAnucleosides; nucleic acids; Introduction
For decades DNA has been known as the carrier of the genetic
Beilstein J. Org. Chem.2006,2, No. 17, doi:10.1186/1860-5397-2-17
containing three (DNAnucleosides) and four (RNA nucleosides) chiral centers respectively. Though the coordination of metal ions to nucleosides is well known, mostly the nucleobase interacts with the metal centre, and the chiral part of the nucleoside is not involved in the coordination. [1][2] Although a